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The Pros and Cons of B12 vs. Lipo B12 Shots

Last Updated: August 29, 2025
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Lipo B12

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As low as $110/Mo
  • Support fat metabolism
  • Weight loss support
  • Increased energy levels
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Some people use vitamin B12 and lipo B12 injections to support their weight loss efforts, but what’s the difference between B12 and lipo B12 injections? One contains only vitamin B12, and the other contains both lipotropes and vitamin B12.

All medications have the potential to cause side effects. When choosing between these medications, consider whether you only need to replenish vitamin B12 or whether you are looking for the benefits associated with lipotropes as well.

B12 vs. Lipo B12 Injections: What’s the Difference?

Vitamin B12 injections restore healthy vitamin B12 levels in people with a deficiency. This deficiency is common, affecting approximately 6% of people under the age of 60 and 20% of people over the age of 60. Though vitamin B12 can be consumed in the diet, many people have difficulty absorbing it and look to alternative ways to maintain healthy B12 levels.

Lipo B12 injections contain lipotropes along with vitamin B12. The combination of lipotropes in any given compound may be proprietary, but most contain the following:

  • Betaine;
  • Branched-chain amino acids;
  • Choline;
  • Inositol;
  • L-carnitine;
  • Methionine;
  • Vitamin B12;
  • Vitamin B6.

Invigor Medical’s lipo B12 injection contains methionine, choline, inositol, and vitamin B12. These nutrients were chosen because they have the most research supporting their benefits.

lipotropics and nutrients

What Are the Pros of Vitamin B12 Injections?

Vitamin B12 injections are typically prescribed for people with symptoms associated with a vitamin B12 deficiency. Vitamin B12 is important for a number of vital functions in the body, such as growth and brain function. It also helps your metabolism work more efficiently, which increases energy and supports weight loss. Epidemiologic studies have shown a link between vitamin B12 and folate deficiencies and increased metabolic risk. This connection has led researchers to focus on better understanding the effect of low vitamin B12 on obesity, insulin resistance, type 2 diabetes, and cardiovascular disease.

What Are the Cons of Vitamin B12 Injections?

According to the National Institute of Health, the Food and Nutrition Board (FNB) didn’t establish an upper limit for vitamin B12 because of its low risk of side effects. However, some people cannot take vitamin B12 injections safely, including those with Leber’s disease or similar eye concerns, kidney disease, liver disease, iron or folic acid deficiency, an active infection, or those taking medications that may interact with vitamin B12.

Are Lipo B12 Injections Right for You?
See if Lipo B12 injections are a fit for your energy, focus, or metabolism goals.
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Vitamin B12 Injection Side Effects

Potential side effects associated with vitamin B12 injections can include the following: 

  • Allergic reactions such as facial swelling and skin rash;
  • Difficulty breathing;
  • Diarrhea;
  • Hand, feet, and ankle swelling.

A very rare but serious allergic reaction that causes swelling of the face, tongue, and throat can occur. Difficulty swallowing or breathing (anaphylaxis) is also possible.

foods high in vitamin B12

What Are the Pros of Lipotropic B12 Injections?

With lipo B12 injections, you get the benefits of vitamin B12 along with the benefits associated with lipotropes. A lipotrope is a substance that helps the body process and remove fat from the liver. The main lipotropics in a lipo B12 injection are inositol, choline, and methionine, each of which performs a critical role in the body.

  • Inositol: Inositol is a sugar alcohol that helps your body use glucose more efficiently. It also contributes to cell structure, metabolism, efficient energy consumption, storage, and fat burning.
  • Choline: Choline is an essential amino acid that is used throughout the body to build cell membranes, maintain healthy muscle and liver function, and produce acetylcholine, a neurotransmitter that regulates mood and is involved in forming memories and controlling muscle contractions. When people have a choline deficiency, they are at increased risk for fatty liver disease.
  • Methionine: Methionine is an essential amino acid that acts as an antioxidant and supplies sulfur to many molecules in the body. It helps to protect body tissues, modify DNA, and maintain healthy cellular function. Because methionine is converted to homocysteine and SAM, it is involved in many steps in fat metabolism.

Because of these additions, lipo B12 injections include the potential for more efficient fat metabolism, better liver health, and increased energy levels.

Vitamin B12 Infographic

What Are the Cons of Lipo B12 Injections?

Lipo B12 injections are generally recognized as safe but do have the potential to cause similar side effects to a standard B12 injection.

Supplements are not appropriate for everyone. Some medical conditions and medications are contraindications to taking supplements. Talk to your doctor about your health concerns to verify that a nutritional deficiency is likely and that supplements such as lipo B12 or B12 injections would improve your health.

Understanding the nuances of vitamin B12 and lipo B12 shots is crucial for anyone looking to enhance their health and weight management efforts. Both options offer unique benefits, from boosting metabolism and energy levels with vitamin B12 to optimizing fat metabolism and liver health with lipo B12’s additional lipotropes. If you’re considering supplementing your diet to combat deficiencies or to support weight loss, buy vitamin B12 injections and take a step towards achieving your health goals.

Lipo B12

In Stock
As low as $110/Mo
  • Support fat metabolism
  • Weight loss support
  • Increased energy levels
NAD+ Vial

Written by

Leann Poston M.D.
Leann Poston M.D.
Licensed Physician and Medical Content Reviewer
Dr. Leann Poston is a licensed physician in the state of Ohio who holds an M.B.A. and an M. Ed. She is a full-time medical communications writer and educator who writes and researches for Invigor Medical. Dr. Poston lives in the Midwest with her family. She enjoys traveling and hiking. She is an avid technology aficionado and loves trying new things.

Medically Reviewed By

Medical Review Process
Every article on Invigor Medical is reviewed by licensed medical professionals to ensure accuracy, clarity, and clinical relevance. Our editorial team works closely with practitioners to verify that content reflects current research, guidelines, and best practices.
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The content provided in this article is for informational and educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always consult with a licensed healthcare provider regarding any medical concerns, conditions, or treatments. Do not disregard medical advice or delay seeking it because of something you have read on InvigorMedical.com.

Invigor Medical does not offer emergency medical care. If you are experiencing a medical emergency, call 911 or go to the nearest emergency room immediately.

Medical treatments discussed on this site may not be appropriate for everyone. All medications require a prescription from a licensed healthcare provider following an appropriate telehealth consultation, and treatment decisions should be made on an individual basis.
Leann Poston M.D.
Leann Poston M.D.
Licensed Physician and Medical Content Reviewer
Dr. Leann Poston is a licensed physician in the state of Ohio who holds an M.B.A. and an M. Ed. She is a full-time medical communications writer and educator who writes and researches for Invigor Medical. Dr. Poston lives in the Midwest with her family. She enjoys traveling and hiking. She is an avid technology aficionado and loves trying new things.

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