What is Ipamorelin?

If you’re looking for a tool to help fight the signs and symptoms of aging, or maybe just want a boost for your energy levels, physical fitness, or metabolism, then you may have come across some discussion of peptides.  Peptides are compounds made up of amino acids, which can act as chemical triggers in the body – binding to certain receptors, and triggering the body to produce or release different hormones or chemicals.  Anti-aging peptides, specifically, are a subset of this group of compounds, and becoming increasingly popular.  For many, they are an effective way to fight the signs and symptoms of aging, as well as to realize specific benefits in a number of bodily systems, with minimal side effects.  One such peptide that has gained a lot of traction in recent years is known as Ipamorelin. 

What is Ipamorelin?

Ipamorelin is a simple peptide, made up of a chain of 5 amino acids.  It’s formally what is known as a growth hormone secretagogue – a compound that is not a growth hormone itself, but promotes and triggers the production of growth hormone in the human pituitary.  In the case of Ipamorelin, it also acts as a ghrelin/growth hormone secretagogue receptor agonist.  In less science-heavy terms, the action of Ipamorelin mimics the action of the natural hormone ghrelin in the body.  Through that process, it triggers human growth hormone production and release from the pituitary gland.  Normally, multiple other chemicals or hormones may also be released in this process (a known issue or side effect of several types of growth hormone releasing peptide formulations), but Ipamorelin is more limited in its action and scope, just focusing in on growth hormone. 

Human Growth Hormone

Human growth hormone is a critical chemical the body uses for a range of different purposes – primarily growth, but much more beyond that.  Growth hormone levels tend to decrease, often substantially, start around age 30.  In fact, on average, adults lose up to 15% of their circulating levels of human growth hormone per decade after 30.  This contributes to many of the various and common “aging” effects, such as decreased energy, increased difficulty in maintaining or building muscle, a slowing metabolism, slowed or less effective injury or wound healing, and more.  Naturally, by increasing levels of human growth hormone, some of these negative effects can be reversed.

How Ipamorelin Works

This is where Ipamorelin comes into play.  Direct treatment with human growth hormone has significant side effects.  Providing synthetic growth hormone directly into the body is not a natural process, causes spikes and uneven levels of hormone circulating in your system, and greatly increases the likelihood of side effects, up to and including serious side effects such as increased cancer risk.  This is not dissimilar from other forms of hormone treatment, such as estrogen or testosterone treatments, in terms of the direct hormone link. 

Peptides like Ipamorelin are different, however, in that they aren’t hormones themselves.  Rather, by mimicking the action of certain triggering molecules and hormones, such as ghrelin, they trigger the body – specifically the pituitary gland – to produce and release its own natural growth hormones, in a consistent, stable way.  This reduces or eliminates the vast majority of the side effects as compared to direct hormonal treatment.  That’s one of the main reasons why anti-aging peptides have become so popular – you get the benefits of hormonal replacement or treatment without the risks.

Benefits and Uses of Ipamorelin

There are numerous potential uses for Ipamorelin, including as a replacement therapy for low levels of human growth hormone in children.  However, most studies on these uses have not been completed in humans, but rather lab animals, and are outside the scope of its use as an anti-aging peptide.  In that context, the release of human growth hormone by Ipamorelin and similar growth hormone releasing peptides has some fairly well-understood benefits and pathways for action.  These include:

  • Increased levels of energy, and better energy metabolism, with decreased fatigue
  • Decreased body fat
  • More easily maintained existing muscle mass, and increased ease to gain new lean muscle mass
  • Higher rates of cellular repair, replication, and regeneration, making it easier to heal from injuries and boosting the immune system
  • Greater bone mineral content, which can be effective at offsetting or decreasing the risk of osteoporosis
  • Improved sleep quality

It’s worth noting that, unlike with some other anti-aging peptides that work in a similar way, Ipamorelin doesn’t trigger the release of additional ghrelin, cortisol, ATCH, or several of the other hormones that can be triggered by conventional growth hormone releasing peptides.  As a result, many of these benefits come without the deleterious effects related to excessive levels of cortisol or ATCH (thus avoiding the blood sugar spiking and bone depleting effects of those substances).

Side Effects and Contraindications for Use of Ipamorelin

Ipamorelin is generally well-tolerated, with few side effects in most people who take it.  Side effects can depend on the dosage and format (see section below).  For our purposes, however, we are talking about Ipamorelin designed for subcutaneous injection, as that is the format available from Invigor Medical (and, in fact, is one of the more common formats for anti-aging peptides today).  Side effects from Ipamorelin include:

  • Redness, itchiness, or irritation at the injection site, which usually is temporary
  • Increased appetite/hunger (though this can also be due to the net effect of a boosted metabolism and more muscle mass gains)
  • Dry mouth
  • Nausea
  • Increased weight (typically due to muscle mass gains and body fat loss, since muscle weighs more than fat)

Excessive water retention may occur, but is rare when used as per proper dosing instructions.  It’s a common symptom of an overdose or taking too much Ipamorelin, however.

Contraindications for usage may exist if you take certain existing medications or supplements, especially those that work on the same biological pathways as Ipamorelin.  This is why it is critical to discuss Ipamorelin use, along with any existing medications, supplements, vitamins, or herbal remedies, as part of your consultation with your doctor, healthcare provider, or telemedicine provider, prior to seeking a prescription for Ipamorelin or beginning an Ipamorelin regimen. 

Ipamorelin Dosage and Format

The Ipamorelin compound is available in several different formats, including oral, nasal, intravenous, and subcutaneous injections.  When delivered via subcutaneous injection (the format most commonly available when you buy Ipamorelin online), it is usually supplied with an intended dose of around 150 micrograms per day, via a single injection.  It is often paired with other anti-aging peptides (see below), such that the total injection amount may be more than 150 micrograms, but usually contains only around 150 micrograms of Ipamorelin.  Subcutaneous injections are usually meant to be made in the stomach or abdominal area.  It is recommended that Ipamorelin typically be taken only once per day, usually at night time, consistent with other anti-aging peptides’ delivery instructions.

Ipamorelin/Sermorelin and Ipamorelin/CJC-1295

Ipamorelin is a relatively short-acting anti-aging peptide in and of itself.  It goes to work quickly in the body, but that activity level also falls off in relatively short order.   The mean half-life of Ipamorelin is around 2 hours, meaning 75% of its efficacy is gone in 4 hours.  This is a different rate than other anti-aging peptides, which can make it an ideal combination drug.  CJC-1295, for example, takes as much as 4 hours to start working, but lasts for as long as a week.  Ipamorelin starts the growth hormone releasing effects, and as its efficacy tails off, the CJC-1295 takes over.  Ipamorelin/CJC-1295 are usually combined in a 1:1 ratio and provided as a blended subcutaneous injection, for a total dosage of 300 mcg (microgram) injection per day.

In the case of Sermorelin, Ipamorelin is actually the longer-acting drug, since Sermorelin works almost instantly and has a half-life of just minutes.  One of the key rationales for combining Sermorelin and Ipamorelin is the different pathways of action.  Because Ipamorelin acts on the ghrelin receptors of the pituitary, while Sermorelin only acts on the growth hormone secreting receptors, you get more “bang for your buck” with the combined substance, providing two separate triggering pathways for the secretion and release of human growth hormone in the body.  Again, as with Ipamorelin/CJC-1295, Ipamorelin/Sermorelin is usually combined in a 1:1 ratio and provided as a blended subcutaneous injection, for a total dosage of 300 mcg (microgram) injection per day.

Where to Buy Ipamorelin Online

Ipamorelin, either on its own or in combination with another anti-aging peptide (as discussed above) is only available by prescription.  You can obtain it from your doctor or healthcare provider, or seek out a telemedicine provider to buy Ipamorelin online.  We strongly encourage you to consider Invigor Medical for your Ipamorelin and other anti-aging peptide needs.  When you are looking to buy Ipamorelin online, you want to choose a telemedicine provider based in the US, that has a reputation for service, and relies on fully licensed and accredited, US-based pharmacies, that also has affordable prices.  That description fits Invigor Medical quite aptly, which is why it has quickly become one of the leading sources for Ipamorelin, anti-aging peptides, and other prescription medications directly via telemedicine consultations today. 

Frequently Asked Questions

Are peptides legal?

Peptides are completely legal substances for use under a doctor or healthcare provider’s supervision, which is why they are only available via prescription.  Because they trigger hormone releases, and have desirable, performance-enhancing effects, they are banned for use in competitive sport by many agencies, sports, and countries.  That does not, however, affect their legal status for use for anti-aging or other beneficial purposes, and simply means that competitive athletes cannot take them while part of a competitive sport. 

What are the benefits of Ipamorelin?

We’ve outlined many of the benefits of Ipamorelin above, but to recap, these include decreased body fat, improved lean muscle mass, higher energy levels, better metabolic rate, improved cellular repair/regeneration and immune health, boosted bone mineral content, and better sleep, among others.

When should you take Ipamorelin?

Generally, Ipamorelin taken on its own, or combined with CJC-1295 or Sermorelin, should be taken in the evening, ideally right before bed, and on an empty stomach.  This helps maximize its efficacy, and follows the natural cycles of your body’s growth hormone production.  Most providers recommend taking Ipamorelin injections every day, or on a 5/7 cycles (meaning 5 out of 7 days a week).  Always follow the prescribing information or recommendations of your doctor for dosage amount, frequency, and time. 

Concluding Thoughts

Ipamorelin is a powerful anti-aging peptide on its own, and can help you to realize significant benefits.  Retaining the energy levels, muscle building capabilities, and metabolism of your younger self can go a long way towards fighting back against the effects of aging.  When combined with other anti-aging peptides, like Sermorelin or CJC-1295, Ipamorelin can help to supercharge this process, providing more effective and noticeable anti-aging results – without a lot of harmful or serious side effects as you would see in direct hormone replacement therapies.  That’s one of the key reasons why so many people have embraced Ipamorelin and other anti-aging peptides as a safe and effective way to reverse the clock and stay fit and healthy well into older age. 

ALSO READ – Sermorelin vs. Ipamorelin