Why You Should Consider Sermorelin

Peptide research and application is becoming the most exciting and promising avenue to travel for advancements in anti-aging. One of the most commonly applied of the signalling molecules for this purpose is called sermorelin acetate. Usually called just sermorelin, this peptide is a growth hormone secretagogue, a.k.a. growth hormone-releasing hormone – it’s functional alias. What it does in the human body can be summed up with that name; it releases growth hormone. You can buy sermorelin injections online but is sermorelin worth it?

However, it’s effects are far more profound than this. Sermorelin has the ability to positively impact systems throughout the body that experience natural degradation as a result of the aging process and it has clear benefits over conventional growth hormone therapies that have been used in the past. If you are thinking about starting sermorelin, look no further for a comprehensive review of this exciting peptide and its ability to improve your quality of life as well as boosting healthspan (how long you are healthy). If you want to buy sermorelin injections online we will also discuss that as well. As we all know, it’s not just about living longer, it’s about living better!

sermorelin injections increase HGH production

So what is sermorelin exactly? Is sermorelin worth it? Is it safe to buy sermorelin injections online? And how does it have the ability to have a positive impact on systems throughout the body? Well, as we said, sermorelin is a growth hormone-releasing hormone (GHRH). This means that is stimulates the natural release of growth hormone (GH) from a specialized bundle of cells in your brain called the pituitary gland. This gland releases hormones that have many jobs all over the body, but as we age, its ability to produce and distribute these chemical messengers declines. Combine this with your decreased capacity to produce GHRH (in another part of your brain called the neurosecretory nerve terminals of the arcuate neurons), and you have a recipe for a growth hormone deficiency.

Although this is a common and expected byproduct of the aging process, it doesn’t have to be this way. We now have the ability to supply your pituitary gland with all the GHRH it needs in the form of sermorelin as well as other varieties of GHRHs. By supplying the key that opens the floodgates for your own natural growth hormone to flow from, we are able to mitigate or prevent the negative effects of growth hormone deficiency such as difficulty or inability to decrease body fat/increase lean mass, lack of appetite, sleep dysfunction, and more. Even better, because sermorelin simply releases our own supply of growth hormone, we are able to avoid the negative effects of conventional growth hormone therapy (more on these later). Sermorelin and all forms of GHRH are classified as pleiotropic, meaning they have more than one effect throughout the body. Separate from the benefits conferred by stimulating the release of growth hormone itself, sermorelin has the ability to bind to peripheral GHRH receptors around the entire body, and it has higher activity and stability than naturally produced GHRH. This means it works better and longer than the GHRH your brain produces on its own. There are additional anti-inflammatory benefits to utilizing compounds like sermorelin but they are typically just a welcomed additional benefit and not a primary reason for administration. 

sermorelin injections for anti-aging

So now that you know the mechanism of action of sermorelin (how it works on a physiological/cellular level), let’s dig into some of the benefits of utilizing this amazing peptide. Keep in mind the list is long and likely to keep growing as more and more research and clinical application occurs. For now we will stick to the most common reason people utilize sermorelin, while just touching on some of the systemic effects that although amazing, aren’t typically the focus of treatment. 

Is Sermorelin Worth it for Anti-aging?

Not that anyone needs a reminder, but the natural aging process degrades nearly every function in the body, especially those not needed for immediate survival. One particularly important function that is profoundly impacted by age is the ability to produce and release growth hormone naturally. Research has shown that natural growth hormone release drops dramatically after around the age of 30. Starting at, on average, 150 µg/kg released per day during puberty, then decreasing to approximately 25 µg/kg/day by age 55 (µg means nanograms, a very small amount but growth hormone is incredibly powerful)¹. This enormous reduction means a decreased ability to build muscle mass, reduced capacity to oxidize (burn) stored body fat for fuel, decreased bone mineral density and wound-healing ability, reduced appetite and sleep, and generally lowered feelings of vitality. This is why sermorelin and other peptides like it are such an impactful therapy, aging just takes a lot out of you (no pun intended)!

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Administering sermorelin at night mirrors the rhythm in which natural growth hormone release would occur and has been shown to reduce visceral (abdominal) fat, increase muscle mass, increase fluid memory, improve sleep and appetite, cause improvements in elastin and collagen production resulting in younger looking skin, and more. All of these effects are why sermorelin and other GHRH mimics can truly be considered anti-aging therapies. Independent of these direct effects, sermorelin has benefits due to the ubiquity of GHRH receptors within us. Binding sites for GHRH are present in the hypothalamus, heart, lymphocytes (immune cells), testes, ovaries, pancreas, skin, and more locations throughout the entire body. Summed up, a reduction in natural growth hormone release is a result of aging, and likely one of many causes of aging as well. By increasing growth hormone release via sermorelin, we are able to fight the aging process on an even playing field which makes it a great tool for anti-aging. So is sermorelin worth it? It is for a lot of people who want to slow the aging of their bodies.

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So Why Not Just Use HGH?

Well for starters, human growth hormone is illegal for use as an anti-aging therapy. If this restriction was removed there would still be substantial reasons for utilizing sermorelin or another GHRH in lieu of HGH. First and foremost is how exogenous (from outside the body) HGH circulates the body all throughout the day. Growth hormone is usually released by the pituitary gland in a pulsatile fashion with the highest amount being released about an hour before you typically go to bed. This is why sermorelin is injected or ingested at this time. When you take exogenous HGH, the levels circulating throughout the body are relatively consistent throughout the day. This results in growth hormone receptors becoming resistant or burning out, much like the insulin receptors in those with Type II diabetes. This abnormal introduction of external HGH puts the user at  risk of immune dysfunction, acromegaly (enlargement of the face, hands, and feet), cardiomegaly (enlargement of the heart), as well as organ growth, malignant transformation, insulin resistance, and increased oxidative damage at the cellular level. How do you avoid all of these unwanted effects? Stimulate the body’s release of it’s own growth hormone instead of injecting unnatural levels of exogenous HGH.

Where Should You Go to Get Sermorelin?

Like all peptide therapies, it is highly recommended that you visit a certified and reputable anti-aging or wellness clinic to receive sermorelin prescription and treatments. Although it is possible to do so, purchasing peptides off of the internet without a prescription (lack of prescription is a major red flag) is inadvisable at best. There are sources however where you can buy sermorelin injections online through telehealth websites. They offer licensed doctors who can consult and prescribe in a safe manner. Gaining muscle and losing body fat will be much easier with the aid of sermorelin and other GHRHs, but a solid training and nutrition protocol will allow for an increased favorable response to the treatment. It is likely you will be asked if you wish to also utilize a GHRP (growth hormone-releasing peptide) with your sermorelin. This is highly recommended as the two classes of peptides work together via different mechanisms of action to increase the effects of growth hormone release in the body. Stay tuned for articles detailing the unique benefits of GHRPs and combining the two compounds. Overall, sermorelin can and should be considered as part of a protocol to reduce the unwanted effects of aging. Is sermorelin worth it? To those that want to reverse the effects of aging, absolutely. We may not be able to stop getting older, but we can live better while it happens!

¹ Garcia JM, Merriam GR, Kargi AY. Growth Hormone in Aging. Is Sermorelin Worth It? Buy Sermorelin Injections Online. 2019 Oct 7. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. https://www.ncbi.nlm.nih.gov/books/NBK279163/